Saturday, June 10, 2017

How to Cure Cancer: A Novel Approach

PET CT scan has revolutionized the treatment of several types of cancer especially Lymphoma (Hodgkin's Disease and aggressive Non Hodgkin Lymphoma), Non Small Cell Lung Cancer, Head and Neck Squamous Cell Cancers and various other cancers that express 18-FDG avidity. 18FDG PET CT provides structual and functional imformation and provides more accurate extent of disease spread and localization of malignancy.
Proposal: To Cure Cancer using 18FDG
Indication: All FDG avid cancers.
Principle: 18 Fluorodeoxyglucose is preferentially concentrated in tumor tissue due to high tumor activity (reportedly 200 times more glycolysis than normal tissue cells). 
Alkylating chemotherapy agents like Cyclophosphamide have high non cell cycle specific tumoricidal property.
If we can successfully conjugate an alkylating agent with an 18FDG radio isotope, we can attain high concentrations of the chemotherapy drug within the tumor tissue while normal tissues are selectively spared (less toxicity). Massive preferential killing of tumor cells can be expected in such  a situation producing a Complete Response (CR) or a Partial Response (PR) of the tumor tissue be it localized disease or the distant metastasis.

Critical Appraisal welcome. For queries, pls comment below. Constructive criticism and genuine doubts can help address the shortcomings and effect design changes accordingly.

Note: If interested to collaborate or participate in the clinical research towards practical implementation of this therapeutic approach, kindly get in touch with me by email to: indranilkhan@live.com

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